2015 Antineoplastics

I. Immunosuppressives

Chemical classes

1. Glucocorticoids: DEXAMETHASONE, PREDNISONE

  • used in the treatment of cancers whose cells express the requisite receptors (e.g. prednisone-sensitive lymphomas)

2. Antibiotics: CYCLOSPORINE, TACROLIMUS

  • used to prevent rejection following bone marrow transplantation
  • other drugs in this chemical class (EVERLOLIMUS, TEMSIROLIMUS) are now known to function as mTOR inhibitors, these drugs have anti-angiogenic, anti-cell proliferation properties, and they can be used to overcome chemotherapy resistance

3. Antibodies and fusion proteins: ALEMTUZUMAB, DENILEUKIN DIFTITUX, IBRITUMOMAB, RITUXIMAB, TOSITUMOMAB

  • used for specific leukemia and lymphomas because they target unique CDs
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 10-may-15 2:32 PM