2015 Antineoplastics

Question 10

Which of the following would you be MOST likely to see following 6-mercaptopurine administration? Answer
            A.        feedback inhibition of xanthine oxidase
            B.        competitive inhibition of dihydrofolate reductase (DHFR)
            C.        increase in GDP and GTP concentrations
            D.        inhibition of the rate limiting step in DNA synthesis
            E.        feedback inhibition of purine nucleoside phosphorylase (PNP)

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM