2015 Antineoplastics

Which of the following would you be MOST likely to see following 6-mercaptopurine administration? Answer
            A.        feedback inhibition of xanthine oxidase
            B.        competitive inhibition of dihydrofolate reductase (DHFR)
            C.        increase in GDP and GTP concentrations
            D.        inhibition of the rate limiting step in DNA synthesis
            E.        feedback inhibition of purine nucleoside phosphorylase (PNP)

• Outline of Sessions
• References
  • Other Lectures
• Session Objectives
  • Previous courses
  • I: General concepts
  • II. Antimetabolites
  • III. Disrupt DNA
  • IV. Antimitotics and Immune system modifiers
  • V. Protein function inhibitors
  • VI. Angiogenesis inhibitors/Differentiating agents/Treatment strategies
  • VII. Antihormone therapy
• Critical Facts
  • I. General concepts
  • II. Antimetabolites
  • III. Disrupt DNA
  • IV. Antimitotics and Immune system modifiers
  • V. Protein function inhibitors
  • VI. Angiogenesis inhibitors/Differentiating agents/Treatment strategies
  • VII. Antihormone therapy
• Resources
  • Pharm Cards
    • Instructions
    • Antineoplastics II
    • Antineoplastics III
    • Antineoplastics IV
    • AntineoplasticsV
    • AntineoplasticsVI
  • iPad/Web game
  • Tables & Summaries
  • Example test questions
    • Hematopoiesis
    • Endocrine