Overview / Hemat Questions / Question 12
Question 12
A patient with acute myeloid leukemia is being treated with gemtuzumab, and develops tumour lysis syndrome. Which of the following would be an appropriate treatment strategy? Answer
A. Switch to a different monoclonal antibody that targets CD33, like rituximab.
B. Decrease the dose of gemtuzumab to 25-30% of normal
C. Decrease fluid intake, to decrease the filtration load on the kidneys.
D. Switch treatment to 6-mercaptopurine.
E. Add a xanthine oxidase inhibitor (like allopurinol) to the treatment regimen.