2015 Antineoplastics

Question 12

A patient with acute myeloid leukemia is being treated with gemtuzumab, and develops tumour lysis syndrome. Which of the following would be an appropriate treatment strategy? Answer
            A.        Switch to a different monoclonal antibody that targets CD33, like rituximab.
            B.        Decrease the dose of gemtuzumab to 25-30% of normal
            C.        Decrease fluid intake, to decrease the filtration load on the kidneys.
            D.        Switch treatment to 6-mercaptopurine.
            E.        Add a xanthine oxidase inhibitor (like allopurinol) to the treatment regimen.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM