2015 Antineoplastics

Drug A inhibits the enzymes at both sites 1 and 2, but acts more on site 2 than site 1. Drug B is activated by the enzyme at site 3, and blocks purine synthesis at site 4. Drug C directly inhibits the enzyme at site 5. The drugs A / B / C are: Answer

1. Methotrexate / 6-Mercapto purine / Hydroxyurea
2. 5-Fluorouracil / 6-Mercaptopurine / Cytarabine
3. Pemetrexed / 6-Mercaptopurine / Hydroxyurea
4. Methotrexate / Cytarabine / Hydroxyurea
5. 5-Fluorouracil / Cytarabine / Gemcitabine
6. Pemetrexed / Cytarabine / Hydroxyurea

• Outline of Sessions
• References
  • Other Lectures
• Session Objectives
  • Previous courses
  • I: General concepts
  • II. Antimetabolites
  • III. Disrupt DNA
  • IV. Antimitotics and Immune system modifiers
  • V. Protein function inhibitors
  • VI. Angiogenesis inhibitors/Differentiating agents/Treatment strategies
  • VII. Antihormone therapy
• Critical Facts
  • I. General concepts
  • II. Antimetabolites
  • III. Disrupt DNA
  • IV. Antimitotics and Immune system modifiers
  • V. Protein function inhibitors
  • VI. Angiogenesis inhibitors/Differentiating agents/Treatment strategies
  • VII. Antihormone therapy
• Resources
  • Pharm Cards
    • Instructions
    • Antineoplastics II
    • Antineoplastics III
    • Antineoplastics IV
    • AntineoplasticsV
    • AntineoplasticsVI
  • iPad/Web game
  • Tables & Summaries
  • Example test questions
    • Hematopoiesis
    • Endocrine