2015 Antineoplastics

Question 18

DNA synthesis pathways

 

Drug A inhibits the enzymes at both sites 1 and 2, but acts more on site 2 than site 1. Drug B is activated by the enzyme at site 3, and blocks purine synthesis at site 4. Drug C directly inhibits the enzyme at site 5. The drugs A / B / C are: Answer

  1. Methotrexate / 6-Mercapto purine / Hydroxyurea
  2. 5-Fluorouracil / 6-Mercaptopurine / Cytarabine
  3. Pemetrexed / 6-Mercaptopurine / Hydroxyurea
  4. Methotrexate / Cytarabine / Hydroxyurea
  5. 5-Fluorouracil / Cytarabine / Gemcitabine
  6. Pemetrexed / Cytarabine / Hydroxyurea
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM