2015 Antineoplastics

Question 21

For questions 20-22: A patient with diffuse histiocytic lymphoma is being treated with the M-BACOP regimen: methotrexate-leucovorin, bleomycin, doxorubicin, cyclophosphamide, vincristine and prednisone.

In this regimen, Answer

  1. methotrexate and leucovorin have a synergistic effect, producing a greater cell kill than each agent produces alone.
  2. doxorubicin followed by vincristine would be an effective recruitment strategy.
  3. the immunosuppressant drug should be given in a low dose, continuous fashion.
  4. none of these drugs could be used to synchronize cancer cells in a particular phase of the cell cycle.
  5. bleomycin and cyclophosphamide are CCS drugs that can be used to force cells to divide.
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM