2015 Antineoplastics

Update iconSESSION I OBJECTIVES: General concepts

  1. List the potential targets and mechanisms of action of antineoplastic drugs.  Be able to rank these with respect to specificity and be able to predict side effects based on the types of cells that are targeted by cytotoxic agents.

  2. Compare and contrast cell cycle specific (CCS) and cell cycle non-specific drugs.

  3. Describe the cell kill hypothesis and its implications for treatment. Develop an appreciation for scheduling and for dosing regimens used to eliminate cancer cells.

  4. List the factors that influence the success of chemotherapy and relate those factors to drug administration and choice of antineoplastic agent.

  5. List the generic mechanisms for antineoplastic drug resistance and the factors that  contribute to the development of resistance.  Be able to give examples of primary, acquired and multidrug resistance.

  6. List the major mechanisms of action of antineoplastic drugs (including any submechanisms), and be able to give at least one example of a drug that fits into each category. Be able to do the same type of listing for chemical classes of these drugs, cell cycle specificity, causes of resistance and major toxicities.

NB. This is an objective that you will have to build on throughout this series of lectures. It may be addressed best by looking at the summary tables.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 5-may-15 2:17 PM