2015 Antineoplastics

SESSION II OBJECTIVES: Drugs that prevent DNA synthesis

  1. Chart the specific enzymes and pathways that are blocked by antimetabolite cancer drugs.  Be able to identify the specific mechanisms of actions of all drugs that prevent DNA synthesis.

  2. Contrast the mechanisms of action of methotrexate with newer antifolates, and identify the mechanisms that make cancer cells more susceptible than normal cells to these drugs (selective toxicity). Understand the principles and advantages of leucovorin rescue.

  3. Compare and contrast the mechanisms underlying the development of resistance to methorexate, 5‑fluorouracil, 6-mercaptopurine and 6-thioguanine.

  4. Identify the unique activation mechanisms for 5-fluorouracil, capecitabine and the purine analogues.

  5. Identify the common and unique side effects of methotrexate, 5-fluorouracil and 6-mercaptopurine.

  6. Differentiate between the mechanisms of action of the antimetabolite agents that block nucleotide synthesis vs. those that act on DNA synthesizing enzymes.

  7. What is tumour lysis syndrome?  How can its effects be minimized?  Explain the concerns related to co-administration of allopurinol and 6-MP.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM