2015 Antineoplastics

SESSION VI OBJECTIVES: Angiogenesis inhibitors and combination chemotherapy

  1. Explain the role of naturally occuring angiogenesis inhibitors in the growth of secondary tumours following surgery, and define rebound angiogenesis

  2. Distinguish among the mechanisms of action of the different types of angiogenesis inhibitors with respect to the proteins that they act on. Diagram the mechanisms of action of angiogenesis inhibitors paying particular attention to the actions of mTOR.

  3. Compare and contrast the mechanisms of action and side effects attributed to bevacizumab, mTOR inhibitors, the anti-angiogenic STIs and thalidomide.

  4. List the advantages of combination chemotherapy and understand the strategies used to design chemotherapy drug regimens. Apply these concepts to the commonly used combination therapies for the treatment of Hodgkin’s disease, non-Hodgkin’s lymphoma, testicular carcinoma and breast cancer.

  5. Define the terms pulse therapy, recruitment, synchrony, and rescue.  Be able to give examples of each type of treatment.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM