GENETICS

cDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking
Int J Cancer. 2001 Feb 15;91(4):474-80

• cDNA microarrays were employed to determine the expression levels of 1,024 selected genes in 54 peripheral blood lymphocyte samples obtained from patients with B-CLL

• expression profiles were correlated with a number of clinical parameters including patient survival and disease staging

• specific genetic markers were associated with a better response to chemotherapy

• studies like these are leading to the idea that cancers can be subtyped, based on their underlying gene mutations, and these analyses can be used to guide treatment decisions