Target tyrosine kinases / Inhibit EGFR / Mechanism
Drugs that target EGFR: CETUXIMAB/PANITUMUMAB, ERLOTINIB/GEFITINIB
Mechanisms of action
- epithelial growth factor receptor (EGFR) tyrosine kinase is overexpressed in a large number of epithelial-derived cancers
CETUXIMAB/PANITUMUMAB
- monoclonal antibodies directed against EGFR
ERLOTINIB (Tarceva/Genetech), GEFITINIB (Iressa/AstraZeneca)
- competitive antagonists of the ATP-binding site of EGFR