2015 Antineoplastics


  • principles of drug selection:
    • active when used alone
    • Example Questiondifferent mechanisms of action (including different mechanisms for the development of resistance) and/or different chemical classes
    • CCNS vs. CCS or active in different stages of cell cycle
    • different toxicities
  • Example questionenables use of more specific strategies (recruitment and synchrony)

  • can result in:
    • synergistic effects (effect greater than the sum of the actions of the individual drugs) à lower doses à decreased toxicity

    • decreased development of resistance

    • broader cell kill in cancers that consist of a heterogeneous turmor cell population
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM