DRUG REGIMENS
-
many drug regimens combine antineoplastic agents in an attempt to select different mechanisms of action, resistance mechanisms and toxicities
- for example:
REGIMEN |
MECHANISM OF ACTION |
RESISTANCE MECHANISMS |
UNIQUE (PRIMARY) TOXICITY |
| ABVD for Hodgkin's disease | |||
Adriamycin = Doxorubicin |
CCNS Intercalating agent |
P-glycoprotein Changes in target Increased inactivation |
Cardiotoxicity Myelosuppression |
CCS (G2) Strand breaks |
Increased DNA repair |
Skin and lungs (not myelosuppression) |
|
CCS (M) Antimitotic |
P-glycoprotein |
Neurotoxicity Myelosuppression |
|
CCNS Alkylating agent |
Nucleophile production Increased DNA repair |
Myelosuppression |
|
-
other regimens that you should examine this way:
- MOPP for Hodgkin's disease:
- COP (+/-D = CHOP) for non-Hodgkin's lymphoma
- PVB for testicular cancer
- FAC for breast cancer
- CMF for breast cancer