Synchrony

SYNCHRONY

using CCS drugs to synchronize cells into simultaneous cell division, so that they are more sensitive to other drugs or radiation
timing the delivery of drugs so that the action of one drug doesn't interfere with the actions of another
Examples:
- HYDROXYUREA followed by radiation
- VINCA ALKALOIDS (M phase) followed by another CCS drug like ETOPOSIDE (S phase)
- METHOTREXATE followed by L-ASPARAGINASE for the treatment of acute lymphocytic leukemia
  - use of these drugs in this order produces a synergistic result (greater cell kill than if the 2 drugs are given independently)