2016 Treatments for Acid-Peptic Diseases

Answer to example question 3

This question primarily tests: drug-drug interactions (specifically modification of pharmacokinetics via alteration of gastric or urine pH --- i.e., alteration of absorption or elimination).

Aspirin is a weak acid that is primarily excreted in the urine.  A decrease in aspirin efficacy could be brought about by either decreased absorption or increased excretion, but not increased absorption or decreased metabolism (therefore C, D, G and H are incorrect).

Aspirin is a weak acid: its absorption will be decreased and its excretion increased at higher pH (therefore A and B are incorrect).

Of option E and F, sodium bicarbonate is much more likely to alkalinize urine than cimetidine (making E the correct answer).

Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:27 PM