2016 Treatments for Acid-Peptic Diseases

Answer to example question 5

This question tests: PPI pharmacokinetics.

PPIs are taken when gastric motility is the lowest, to avoid breaking the acid protective coatings that prevent drug degradation in the stomach.

PPIs are absorbed from the small intestine.

PPIs can be taken once per day, since they are irreversible inhibitors.

PPIs require low pH in the parietal cell to function (only active pumps are blocked), so they shouldn’t be taken with H2 blockers.

The correct answer is A:  1 hour before a meal allows the matching of peak serum concentrations to match maximal pump activity.

Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:27 PM