2016 Treatments for Acid-Peptic Diseases

You encounter a patient who is infected with a strain of H. pylori that is resistant to the antibiotics used in the currently recommended treatment regimens.  Assuming that a proton pump inhibitor is also prescribed for this patient, which of the following properties would an appropriate alternative antimicrobial drug have? Answer

1. a higher MIC90 value than azithromycin
2. equivalent acid stability to amoxicillin
3. requirement for a gastric pH of <2
4. narrow spectrum of activity, restricted to gram positive bacteria
5. poor oral availability