2016 Treatments for Acid-Peptic Diseases

Proton pump inhibitors should be taken approximately 1 hour before a meal because that: Answer

1. allows peak serum concentrations to coincide with maximal pump activity.
2. is when gastric motility is the greatest.
3. represents the time when gastric pH is the lowest, allowing the inhibitors to be more completely absorbed from the stomach.
4. results in maximal effectiveness (PPIs must be taken at least 3 times per day to be effective).
5. is the only timing that allows other agents that decrease intragastric acidity (such as H₂ blockers) to be taken simultaneously with PP