2016 Treatments for Acid-Peptic Diseases

Absorption and excretion of weak acids and bases

GASTRIC ABSORPTION
EXCRETION
Low pH (<2)
NORMAL
Low pH (<8*)
NORMAL
Weak acids
HA ↔ H+ + A-
more
decrease
less
increase
Weak bases
BOH ↔ B+ + OH-
less
increase
more
decrease
     
* urine pH normally varies between 4 and 8; the exact effect on excretion will depend on the pKa of the specifc drug
Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:27 PM