Treatment / Reduce acidity / Block stimulation
Drugs that block stimulation of acid secretion
-
from a pharmacological perspective, there are two important regulatory mechanisms which can cause an increase in gastric acid secretion:
- release of acetylcholine (ACh) from the neurons of the enteric nervous system, which acts on M3 receptors:
- on the parietal cell, to directly increase H+ secretion
-
on enterochormaffin-like (ECL) cells, to cause:
- release of histamine from ECL cells, which acts on H2 receptors to increase H+ secretion
- release of acetylcholine (ACh) from the neurons of the enteric nervous system, which acts on M3 receptors:
-
therefore, intragastric acidity can be reduced by antimuscarinics and H2 receptor antagonists