2016 Treatments for Acid-Peptic Diseases

Buffer acid
ALUMINUM HYDROXIDE, CALCIUM CARBONATE, MAGNESIUM HYDROXIDE, SODIUM BICARBONATE

Factors affecting usefulness

  1. Systemic absorption
    • good antacids ARE NOT absorbed systemically
      e.g., NaHCO3 is absorbed systemically, and has the most serious side effects

  2. Rate of dissolution
    • SLOW (e.g., Al(OH)3) à slow onset, long duration of action
    • FAST (e.g., NaHCO3) à rapid onset, short duration of action

  3. Effects of cation and/or reaction products
    • Al3+ is CONSTIPATING

    • Mg2+ is CATHARTIC

    • CaCO3 and NaHCO3 produce CO2, resulting in gastric distention and belching

Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:27 PM