2016 Treatments for Acid-Peptic Diseases

Proton pump inhibitors

Critical fact icon
Proton pump inhibitors are the most effective agents for reducing intragastric acidity because they IRREVERSIBLY block the final common pathway in acid secretion --- H+/K+ ATPase.

Mechanism of action

One final note:  PPIs have only modest efficacy in treating non-ulcer-related dyspepsia (10-20% compared to placebo).  Despite marketing claims to the contrary, PPIs have not been conclusively shown to be superior to either H2 antagonists or antacids in providing symptomatic relief for heartburn.

Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:27 PM