2016 Treatments for Acid-Peptic Diseases

Treatment strategies

Eliminate major cause

  1. Eradicate H. pylori
    à antimicrobials

Click here to download animationAcid secretion animation

Parietal cells contain receptors for: gastrin, histamine (H2) and acetylcholine (M3). Stimulation of these receptors increases intracellular Ca2+ (gastrin, M3) or cAMP (H2), either of which results in activation of H+K+-ATPase (the proton pump). Prostaglandins decrease cAMP, reducing acid secretion.

Reduce intragastric acidity

  1. Block stimulation of acid secretion à antimuscarinics, antihistamines
  2. Block acid secretion à proton pump inhibitors
  3. Buffer acid à antacids

Protect the Mucosa

  1. Protective agents
  2. Replace prostaglandins à misoprostol
Email: Dr. Janet Fitzakerley | ©2016 University of Minnesota Medical School Duluth Campus | Last modified: 7-jan-16 8:56 PM