2015 Therapeutic Proteins

Myeloid growth factors

Mechanism of Action

Pharmacokinetics

Therapeutic Uses

Side effects

FILGRASTIM/PEGFILGRASTIM

LIFE-THREATENING:

 

 
  SERIOUS INNOCUOUS
COMMON

 

  • mild/moderate bone pain
    (F/P better tolerated than S)
RARE
  • allergic reactions
  • splenic rupture
 

SARGRAMOSTIM

LIFE-THREATENING:

 

 
  SERIOUS INNOCUOUS
COMMON

 

  • capillary leak syndrome (peripheral edema, pleural or pericardial effusions) – some patients are extremely sensitive
  • moderate/severe bone pain
    (F/P better tolerated than S)
  • fever
  • malaise
  • arthralgias
  • myalgias
RARE
  • allergic reactions
 

 

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 27-apr-15 1:11 PM