2015 Therapeutic Proteins

Example QuestionNomenclature for monoclonal antibodies and fusion proteins

from Ballow (2005) Am. Acad. Allergy Asthma and Immunology
AS WITH MOST PHARMACOLOGY NAMING RULES, THERE ARE EXCEPTIONS!!!

Formation of name: [Drug company term] [ Target] [Source Identifier] MAB

Source Identifiers
(i.e., species that the product was obtained from)
General Disease or Target
last consonant often dropped
to make the name more pronouncable
Tumours
u = human
vir = viral
col = colon
o = mouse
bac = bacterial
mel = melanoma
xi = chimeric
lim = immune
mar = mammary
zu = humanized
les = infectious lesions
got = testis

e.g., TRASTUZUMAB is a humanized monoclonal antibody
IBRITUMOMAB is a mouse monoclonal antibody

Knowing the source of an antibody allows you to predict the severity of side effects!

A notable exception!  ABCIXIMAB is a HUMANIZED monoclonal antibody

cir = cardiovascular
gov = ovary
e.g., ABCIXIMAB is anti-platelet
PALIVIZUMAB is anti-viral
ADALIMUMAB is a rheumatoid arthritis treatment
pr(o) = prostate
tum = misc
e.g., ALEMTUZUMAB is a CLL treatment
EDRECOLOMAB is used to treat colon cancer
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 27-apr-15 1:24 PM