2015 Therapeutic Proteins

Lecture Objectives

  1. Understand the theory behind the design of therapeutic proteins, esp. mouse/human antibodies, “peptibodies” and fusion proteins.  Describe the difference between chimeric, humanised and human antibodies, and relate these differences to therapeutic efficacy and side effects.

  2. Know the common routes of administration and side effects of antibodies when used as therapeutic agents. Understand and be able to apply the rules for naming therapeutic antibodies, and be able to identify common strategies and themes for antibody design.

  3. Identify the disadvantages and common side effects that arise during cytokine therapy.

  4. Be able to identify the specific hematopoietic agent(s) that can be used clinically to stimulate production of particular types of blood cells, and the unique side effects for each agent. Be able to relate mechanism of action to therapeutic use(s) for erythroid, myeloid and megakaryocyte growth factors. Identify the specific advantages and disadvantages of PEG'd compounds compared to their naturally occurring counterparts.

For the test based on this lecture, you DO NOT need to memorize the details of all of the therapeutic proteins available for use as therapeutics --- with the exception of the hematopoietic agents.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 27-apr-15 1:11 PM