Overview / Example test questions / Q2
Example Test Question 2
Compared to the folate receptor, the reduced folate carrier is MORE likely to: Answer
- be upregulated during the development of methotrexate resistance.
- require internalization (potocytosis), making uptake a slow process.
- be important when antifolates are given at pharmacological concentrations.
- transport methotrexate preferentially to leucovorin.
- be overexpressed in some epithelial cancers, making them more sensitive to methotrexate.