2015 Folate, Vitamin B12 and Inhibitors

Example Test Question 2

Compared to the folate receptor, the reduced folate carrier is MORE likely to: Answer

    1. be upregulated during the development of methotrexate resistance.
    2. require internalization (potocytosis), making uptake a slow process.
    3. be important when antifolates are given at pharmacological concentrations.
    4. transport methotrexate preferentially to leucovorin.
    5. be overexpressed in some epithelial cancers, making them more sensitive to methotrexate.
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 4-may-15 9:28 PM