2015 Folate, Vitamin B12 and Inhibitors

Lecture objectives

    1. Be able to describe the specific functions of FOLIC ACID and VITAMIN B12, and relate these functions to the therapeutic effects of METHOTREXATE and TRIMETHOPRIM.

    2. Explain the mechanism by which the folate transporter and the reduced folate carrier is involved in the differential sensitivity of cancer cells and bacteria to folic acid inhibitors.

    3. Know the consequences of FOLATE and VITAMIN B12 deficiency, and strategies for replacement. Be able to explain the clinical relevance of the controversy over folate fortification of foods.

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 4-may-15 9:28 PM