2016 Lower GI Pharmacology

Mechanisms of Action

• DOCUSATE is a surfactantà softens stool by allowing mixing of aqueous and fatty substances

• MINERAL OIL lubricates feces à decreased water absorption from stool

Therapeutic uses

• despite widespread clinical use, stool softeners have marginal efficacy in most cases of constipation

Side effects

Although stool softeners are considered the mildest laxatives, like all laxatives/cathartics, they should not be used in cases of undiagnosed abdominal pain or unknown intestinal pathology. MINERAL OIL may result in severe lipid pneumonitis if aspirated and long term use can cause decreased absorption of fat soluble vitamins (A, D, E, K).

• Stool softeners
• Absorbants