Water balance / BABRs
Bile acid binding resins
CHOLESTYRAMINE, COLESTIPOL
Mechanism of action & Therapeutic Uses
- diseases of the terminal ileum (e.g., Crohn’s disease) or surgical resection → malabsorption of bile salts → increased bile salts in lumen cause water secretion → secretory diarrhea
- BABR's complex with bile salts in lumen, and result in decreased water secretion
Side effects
-
frequent “untoward” GI effects (bloating, flatulence, constipation, fecal impaction)
-
impaired intestinal absorption of concurrently administered drugs and fat-soluble vitamins