2014 Neural Communication

Neurotransmitter release

Critical fact icon
Neurotransmitter release from the presynaptic terminal consists of a series of intricate steps: 1) depolarization of the terminal membrane, 2) activation of voltage-gated Ca2+ channels, 3) Ca2+ entry, 4) a change in the conformation of docking proteins, 5) fusion of the vesicle to the plasma membrane, with subsequent release of neurotransmitter into the synaptic cleft. The neurotransmitter release mechanisms are disrupted in several diseases and by some biological toxins.

 

Depolarization-Release Coupling

Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 20-nov-14 2:38 PM