2012 Drugs that promote or inhibit coagulation

Anticoagulants

The major classes of anticoagulant drugs have distinctly different mechanisms of action, routes of administration and adverse effects. Critical fact icon

Mechanisms of Action

1. Indirect inhibition of thrombin

A. Activation of antithrombin III e.g., HEPARIN

B. Inhibition of factor Xa e.g., RIVAROXABAN

2. Direct inhibition of thrombin e.g., HIRUDIN

3. Inhibition of synthesis of blood coagulation factor precursors (zymogens) e.g., WARFARIN

Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 31-may-12 8:29 PM