2012 Drugs that promote or inhibit coagulation

Pharmacokinetics

• given IV

• "RUDINs" and DABIGATRAN are excreted by kidney

• ARGATROBAN metabolized by liver

• monitored (if necessary) by aPTT
  • ARGATROBAN causes elevated INRs because of test interference, making the transition to WARFARIN difficult

• Mechanisms of action
• Indirect thrombin inhibitors
  • ATIII Activators
    • Mechanism of action
    • Pharmacokinetics
    • LMW Heparins
    • Therapeutic uses
    • Adverse effects
    • Protamine sulfate
  • Factor Xa inhibitors
• DTIs
  • Mechanism of action
  • Pharmacokinetics
  • Therapeutic uses
  • Adverse effects
• Zymogen synthesis inhibitor
  • Mechanism of action
  • Pharmacokinetics
  • Therapeutic uses
  • Adverse effects
    • Interactions
    • Increased actions
    • Decreased actions
    • Drug interaction theory
    • Specific drug interactions
  • Phytonadione