2012 Drugs that promote or inhibit coagulation

Activators of Antithrombin III: HEPARIN,
FONDAPARINUX,
LMW HEPARINS: DALTEPARIN, DANAPAROID, ENOXAPARIN

LMW Heparins

Greater than HEPARIN
Less than HEPARIN
Anti Xa activity
Inactivation of thrombin (IIa)
Bioavailability (SC administration)
Platelet inhibition
Half-life decreased dosing
Plasma protein binding
More predictable pharmacology
less need for monitoring
(monitoring generally not needed except during pregnancy)

 

Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 31-may-12 8:59 PM