2012 Drugs that promote or inhibit coagulation

Inhibitors of zymogen synthesis: WARFARIN

Adverse effects

WARFARIN

  • has a NARROW THERAPEUTIC INDEX

  • is NEARLY COMPLETELY (99%) BOUND TO PLASMA ALBUMIN

  • is ELIMINATED BY HEPATIC METABOLISM (CYP450)

à WARFARIN IS THE PROTOTYPE FOR DRUG-DRUG INTERACTIONS!

Critical fact icon
Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 31-may-12 7:25 PM