Fibrinolytic inhibitors

Fibrinolytic inhibitors: AMINOCAPROIC ACID (EACA), APROTININ

these agents are used in life-threatening situations (such as surgical complications), and as antagonists to fibrinolytic agents
AMINOCAPROIC ACID (EACA) inhibits plasminogen activation
- used to counteract tPAs
- side effects include intravascular thrombosis, hypotension, myopathy and GI disturbances
APROTININ is a serine protease inhibitor that prevents fibrinolysis by inhibiting the plasmin-streptokinase complex
- used to counteract streptokinase