2012 Drugs that promote or inhibit coagulation

Answer to example question 1

This question tests: the treatment of bleeding disorders and agents that reverse the actions of heparin and the oral anticoagulants.

While all of these drugs are procoagulant, desmopressin acetate is the agent used to increase factor VIII activity in patients with mild hemophilia A or von Willebrand’s disease who are going to undergo minor surgery (C is the correct answer).  Aminocaproic acid and aprotinin are fibrinolytic inhibitors that are used for life-threatening complications and as antagonists to fibrinolytic agents (tPA and streptokinase, respectively).  Phytonadione (vitamin K) is a warfarin antagonist, while protamine sulfate is a heparin antagonist.

Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 31-may-12 7:25 PM