2012 Drugs that promote or inhibit coagulation

Answer to example question 3

This question tests: define how drugs interact with coagulant and fibrinolytic pathways.

Fibrinolytic drugs target the conversion of plasminogen to plasmin.  Drotrecogin alfa targets factors Va and VIIIa.  Heparin activates antithrombin III to destroy IIa, IXa, Xa and XIa.  Warfarin prevents the generation of vitamin K-dependent zymogens (i.e., II, VII, IX and X NOT IIa, VIIa, IXa and Xa).  The correct answer is C.

Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 31-may-12 7:25 PM