INHIBITORS,
INDUCERS AND SUBSTRATES
OF CYTOCHROME P450 ISOZYMES
remember
inhibitors and substrates INCREASE the
effectiveness of another drug metabolized by that isozyme
inducers DECREASE effectiveness
| INHIBITORS | INDUCERS | SUBSTRATES | INHIBITORS | INDUCERS | SUBSTRATES | ||
| CYP1A2 | CYP3A4 | ||||||
| cimetidine ciproflxacin enoxacin erythromycin ***fluvoxamine grepafloxacin isoniazid mexiletine norfloxacin tacrine zileuton |
barbiturates carbamazepine charcoal-broiled foods lansoprazole omeprazole phenytoin rifampin smoking |
amitriptyline caffeine clomipramine clozapine cyclobenzaprine grepafloxacin imipramine mirtazapine |
olanzapine propranolol riluzole ropinirole R-warfarin tacrine theophylline zileuton |
amiodarone amprenavir clarithromycin cyclosporine danazol delavirdine diltazem efavirenz erythromycin ethinylestradiol fluconazole fluvoxamine grapefruit juice indinavir itraconazole ketoconazole nefazodone nelfinavir quinine ***ritonavir saquinavir Synercid troleandomycin verapamil zafirlukast |
barbiturates carbamazepine dexamethasone efavirenz ethosuximide griseofulvin modafinil nafcillin nevirapine oxcarbazepine phenytoin primidone rifabutin ***rifampin rifapentine St. John's wort |
alfentanil alprazolam amiodipine amprenavir atorvastatin bepridil buspirone carbamazepine cerivastatin cisapride citalopram clarithromycin clomipramine corticosteroids cyclophosphamide cyclosporine dapsone delavirdine diazepam diltiazem disopyramide dofetilide donepezil doxorubicin efavirenz erythromycin ethinylestradiol etoposide felodipine fentanyl finasteride ifosfamide imipramine indinavir isradipine itraconazole ketoconazole lansoprazole loratadine losartan |
lovastatin methadone midazolam mirtazapine montelukast nefazodone nelfinavir nicardipine nifedipine nimodipine nisoldipine paclitaxel pimozide quetiapine quinidine quinine repaglinide refabutin ritonavir saquinavir sertraline sibutamine sildenafil simvastatin sirolimus sufentanil tacrolimus tamoxifen testosterone tolterodine toremifene triazolam troleandomycin verapamil vinblastine vincristine R-warfarin zaleplon zileuton zolpidem zonisamide |
| CYP2C9 | |||||||
| amiodarone cimetidine cortrimoxazole fluconazole ***fluvoxamine isoniazid ketoconazole metronidazole zafirlukast |
barbiturates carbamazepine rifampin rifapentine St. John's wort |
carvedilol celecoxib diclofenac flurbiprofen fluvastatin glimepiride ibuprofen irbesartan losartan |
montelukast naproxen phenytoin piroxicam tolbutamide torsemide S-warfarin zafirlukast |
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| CYP2C19 | |||||||
| felbamate fluoxetine fluvoxamine modafinil omeprazole oxcarbazepine |
None | amitriptyline citalopram clomipramine diazepam imipramine |
lansoprazole phenytoin omeprazole R-warfarin |
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| CYP2D6 | |||||||
| amiodarone chloroquine cimetidine clomipramine diphenhydramine fluoxetine fluphenazine haloperidol paroxetine perphenazine propafenone propoxyphene quinacrine quinidine ritonavir sertaline terbinafine thioridazine |
None | amitriptyline carvedilol chlorpromazine clomipramine clozapine codeine desipramine dextromethorphan dihydrocodeine donepezil flecainide fluoxetine haloperidol hydrocodone imipramine loratadine maprotiline methamphetamine |
metoprolol mexiletine mirtazpine nortriptyline oxycodone paroxetine perphenazine propafenone propanolol risperidone ritonavir thoridazine timolo tolterodine tramadol trazodone venlafaxine |
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