2012 Drugs that promote or inhibit coagulation

Question 2

A patient is being released from the hospital following a myocardial infarction, and is being transitioned to 2-6 months of warfarin therapy.  He is currently taking amiodarone (an antiarrythmic drug), atorvastatin (an antihyperlipidemic) and nafcillin (to treat a Staphylococcus infection acquired in the hospital).  He routinely drinks grapefruit juice for breakfast.  Using the accompanying drug interaction table as a guide, which of the following interactions is MOST LIKELY to occur? Answer
            A.        Atorvastatin increasing the efficacy of warfarin.
            B.        Amiodarone increasing the efficacy of atorvastatin.
            C.        Grapefruit juice increasing the efficacy of warfarin.
            D.       Amiodarone increasing the efficacy of nafcillin.
            E.        Atorvastatin increasing the efficacy of warfarin.
            F.        Nafcillin increasing the efficacy of atorvastatin.

Email: Dr. Janet Fitzakerley | ©2012 University of Minnesota Medical School Duluth | Last modified: 4-jun-13 3:25 PM