Thrombolytics / Streptokinase
Thrombolytics: STREPTOKINASE
Mechanism of Action
-
STREPTOKINASE binds to and induces a conformational change in plasminogen resulting in exposure of the active site and facilitating the conversion to plasmin (STREPTOKINASE itself is not intrinsically active)
Adverse Effects
-
may evoke allergic hypersensitivity reactions (fever and anaphylaxis), particularly with repeated treatment or in patients with a recent history of streptococcal infection