2012 Drugs that promote or inhibit coagulation

Mechanism of Action

• kidney enzyme that directly converts plasminogen to active plasmin

• primarily indicated only for patients allergic to streptokinase

Adverse Effects

• febrile episodes are common, but infusion reactions and hypersensitivity (anaphylaxis) are rare

• Common features
• Common contraindications
• Streptokinase
• Urokinase
• tPAs