2007 Sensory Physiology

Transduction

Olfactory transduction pathways

  ORNs GC-D VNO
Odours
1000
????
pheremones
G protein
Golf
Guanylate Cyclase D
Gαi2 and Gαo
Effector protein

Adenylate cyclase III
(increases cAMP)
PDE-2
(decreases cGMP)
Phospholipase C
(generates DAG)
Channel
opens OCNC1
(non-specific cation channel)
closes cGMP-specific cation channel
(similar to cones)
opens transient receptor potential
channel TRPC2

 

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