|
MATTHEW T. ANDREWS
McKnight Presidential Professor of Biology
Director, Bio-Translational Research Center
B.S., 1979, University of Michigan Ann Arbor
Ph.D., 1984, Wayne State University School of Medicine, Detroit
Email: mandrews@d.umn.edu
Office: 253D SSB
Phone: 218-726-7271 |
Research Interests
Genetic factors controlling mammalian hibernation
Research in my laboratory is directed toward the characterization of genes responsible for the induction and maintenance of hibernation in mammals. Hibernating mammals provide a unique system for identifying molecules that are important in regulating metabolism, body temperature and sleep. In a state of deep hibernation, body temperature is only a few degrees above 0°C, oxygen consumption holds at 1/30 to 1/50 of the aroused condition and heart rate can be as low as 3-10 beats/minute, compared to 200-300 beats/minute when the animal is awake and active. We are currently using RNAseq to identify genes that are responsible for the physiological characteristics of hibernation in the thirteen-lined ground squirrel Ictidomys tridecemlineatus. A recent study examining the transcriptome of heart, skeletal muscle and white adipose tissue can be found at: http://dx.plos.org/10.1371/journal.pone.0027021
Hibernation is seen in a wide-range of taxa including rodents, carnivores, insectivores, bats and even primates. Since the majority of species within these groups do not hibernate, it has been proposed that hibernation results from the differential expression of genes common to all mammals rather than the evolution of new genes unique to the hibernating species. Determining the function of gene products involved in hibernation is one of the main goals of the laboratory and has applications in the areas of hypothermia, ischemia/reperfusion injury, cardiac function and organ preservation.
TV interview on hibernation
Development of blood-loss therapy
Recent Publications
-
Hampton, M., Melvin, R.G., Kendall, A.H., Kirkpatrick, B., Peterson, N. and Andrews, M.T. (2011) Deep sequencing the transcriptome reveals seasonal adaptive mechanisms in a hibernating mammal. PLoS ONE 6(10): e27021.
-
Klein, A.H., Wendroth, S.M., Drewes, L.R., and Andrews, M.T. (2010) Small volume D-beta-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats. Shock, 34, 565-572.
-
Hampton, M., Nelson, B.T., and Andrews, M.T. (2010) Circulation and metabolic rates in a natural hibernator: an integrative physiological model. Am. J. Physiol. 299, R1478-1488.
- Melvin, R.G. and Andrews, M.T. (2009) Torpor induction in mammals: recent discoveries fueling new ideas. Trends Endocrinol. Metab. 20, 490-498.
- Andrews, M.T., Russeth, K.P., Drewes L.R., Henry, P.G. (2009) Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor. Am. J. Physiol. 296, R383-393.
- Henry, P.G., Russeth, K.P., Tkac, I., Drewes, L.R., Andrews, M.T., and Gruetter, R. (2007) Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo 1H MRS study of a hibernating mammal. J. Neurochem. 101, 1505-1515.
- Andrews, M.T. (2007) Advances in molecular biology of hibernation in mammals. Bioessays 29, 431-440.
- Hampton, M. and Andrews, M.T. (2007) A simple mathematical molecular model of mammalian hibernation. J. Theor. Biol. 247, 297-302.
- Russeth, K.P., Higgins, L., and Andrews, M.T. (2006) Identification of proteins from non-model organisms using mass spectrometry: Application to a hibernating mammal. J. Proteome Res. 5, 829-839.
Teaches
-
BIOL 5199 Frontiers in Cell Biology
-
BIOL 5233 Genomics
- IBS 8011 Integrated Biological Systems
- IBS 8020 Colloquia
Current Graduate Students
- Brian Kirkpatrick
- Bethany Nelson
Recent UROP students
Top of page |
